Enriched sites across MLM knockout quintiles. Plots show the proportion of significantly enriched sites identified by MACS (y-axis) for marks shown in the legend across the data divided by quintiles of log2 fold change (WT/KO) in gene expression predicted by the MLM for H4R3me2, (A)-(C), and H3K27me2, (D)-(F), knockouts. Proportions of sites were clustered using k-means clustering. For both knockouts activating marks clustered together, (A) and (D), as did arginine methylations, (B) and (E), and repressive marks, (C) and (F). H4R3me2 knockout effect only shows a strong correlation with other arginine methylations (B), while the H3K27me3 knockout effect shows strong anti-correlation with the activating marks (A) and strong positive correlation with other repressive marks (F).