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Table 1 Multilinear model terms and statistics

From: Application of machine learning methods to histone methylation ChIP-Seq data reveals H4R3me2 globally represses gene expression

Multilinear model term β (trim mean) Z (trim mean) p (median) Impact (trim mean)
H3K79me1 a 6.741 18.234 0 1.331
H3K36me3 a 4.087 17.802 0 0.922
H3K79me3 a 3.078 23.916 0 0.598
H4K20me1 a 0.977 21.446 0 0.450
H3K4me2 a * - H3R2me1 r 18.270 7.850 1.66E-15 0.437
H3K27me2 r * - H3R2me1 r 70.468 15.280 0 0.381
H3K9me2 r * - H3K27me1 r * - H4K20me1 a 37.041 5.643 9.47E-09 0.156
H3K4me3 a 0.133 5.729 5.20E-09 0.151
H2BK5me1 a * - H3K36me3 a 1.286 3.800 7.95E-05 0.115
H2BK5me1 a * - H4K20me1 a - H3R2me1 r 1.531 6.034 1.14E-09 0.030
Intercept 4.026 64.131 0 0
H3K9me3 r * - H3K36me3 a -2.747 -12.439 0 -0.010
H3K4me2 a * - H3K36me3 a - H3K79me3 a -1.274 -3.743 1.02E-04 -0.018
H3K36me3 a - H3K79me2 - H3R2me2 -5.855 -3.497 1.73E-04 -0.022
H3K27me3 r * - H3K79me2 - H3K79me3 a -26.341 -6.380 5.78E-11 -0.026
H3K4me1 a * - H3K9me2 r * - H4K20me1 a -4.563 -3.578 2.65E-04 -0.041
H3K9me1 a * - H3K27me1 r * - H4K20me1 a -2.350 -5.078 1.92E-07 -0.077
H2BK5me1 a * - H4K20me1 a -0.600 -9.627 0 -0.095
H3K36me1 - H3K79me1 a - H3K79me3 a -27.840 -8.478 0 -0.115
H3K4me2 a * - H3K9me1 a * -1.578 -3.340 3.57E-04 -0.123
H4R3me2 r -11.121 -13.233 0 -0.301
H3K27me2 r * - H3K36me3 a -31.772 -8.911 0 -0.311
H3K27me2 r * - H3K79me1 a -56.535 -9.535 0 -0.449
H3R2me1 r -11.937 -16.504 0 -0.596
  1. Terms appearing in the final multilinear model, and associated statistics. Trim mean of the β coefficients, Z-scores and impact factors (β multiplied by amplitude interquartile range). Trim mean is defined as the mean of the population excluding the lowest and highest 5% of the data. The superscript labels each mark as activating (a) or repressive (r). Unstarred marks correspond to monovalent terms in the model, starred marks do not have a monovalent contribution in the model, but correlated/anti-correlated with gene expression based on univariate analysis, and uncolored marks do not have clear correlation with gene expression. Rows are sorted by the impact term value.