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Table 1 Multilinear model terms and statistics

From: Application of machine learning methods to histone methylation ChIP-Seq data reveals H4R3me2 globally represses gene expression

Multilinear model term

β (trim mean)

Z (trim mean)

p (median)

Impact (trim mean)

H3K79me1 a

6.741

18.234

0

1.331

H3K36me3 a

4.087

17.802

0

0.922

H3K79me3 a

3.078

23.916

0

0.598

H4K20me1 a

0.977

21.446

0

0.450

H3K4me2 a * - H3R2me1 r

18.270

7.850

1.66E-15

0.437

H3K27me2 r * - H3R2me1 r

70.468

15.280

0

0.381

H3K9me2 r * - H3K27me1 r * - H4K20me1 a

37.041

5.643

9.47E-09

0.156

H3K4me3 a

0.133

5.729

5.20E-09

0.151

H2BK5me1 a * - H3K36me3 a

1.286

3.800

7.95E-05

0.115

H2BK5me1 a * - H4K20me1 a - H3R2me1 r

1.531

6.034

1.14E-09

0.030

Intercept

4.026

64.131

0

0

H3K9me3 r * - H3K36me3 a

-2.747

-12.439

0

-0.010

H3K4me2 a * - H3K36me3 a - H3K79me3 a

-1.274

-3.743

1.02E-04

-0.018

H3K36me3 a - H3K79me2 - H3R2me2

-5.855

-3.497

1.73E-04

-0.022

H3K27me3 r * - H3K79me2 - H3K79me3 a

-26.341

-6.380

5.78E-11

-0.026

H3K4me1 a * - H3K9me2 r * - H4K20me1 a

-4.563

-3.578

2.65E-04

-0.041

H3K9me1 a * - H3K27me1 r * - H4K20me1 a

-2.350

-5.078

1.92E-07

-0.077

H2BK5me1 a * - H4K20me1 a

-0.600

-9.627

0

-0.095

H3K36me1 - H3K79me1 a - H3K79me3 a

-27.840

-8.478

0

-0.115

H3K4me2 a * - H3K9me1 a *

-1.578

-3.340

3.57E-04

-0.123

H4R3me2 r

-11.121

-13.233

0

-0.301

H3K27me2 r * - H3K36me3 a

-31.772

-8.911

0

-0.311

H3K27me2 r * - H3K79me1 a

-56.535

-9.535

0

-0.449

H3R2me1 r

-11.937

-16.504

0

-0.596

  1. Terms appearing in the final multilinear model, and associated statistics. Trim mean of the β coefficients, Z-scores and impact factors (β multiplied by amplitude interquartile range). Trim mean is defined as the mean of the population excluding the lowest and highest 5% of the data. The superscript labels each mark as activating (a) or repressive (r). Unstarred marks correspond to monovalent terms in the model, starred marks do not have a monovalent contribution in the model, but correlated/anti-correlated with gene expression based on univariate analysis, and uncolored marks do not have clear correlation with gene expression. Rows are sorted by the impact term value.