Figure 5
From: Global parameter estimation methods for stochastic biochemical systems
Effect of the finite sampling noise on the parameter estimation of E. coli RNA dynamics model. Normalized objective function contours of the DFD-PDF method for SSA realizations of 10,000 (A), 5000 (B), and 1000 (C). The parameter values k 2 and k 3 were varied between 0.1 and 1 while keeping the value of k 1 at its original value. The normalization was done with respect to the optimal solution from each case, where the white circles represent the extrema on the normalized objective function plane.