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Figure 1 | BMC Bioinformatics

Figure 1

From: FACT: Functional annotation transfer between proteins with similar feature architectures

Figure 1

Overview of FACT. (A) The amino acid sequence of query protein Q serves as input for a collection of prediction programs, which annotate Q with features from Φ. (B) The assembly of instances from Φ constitute the feature architecture of a protein. (C) The FACT score captures the similarity between two feature architectures by a combination of the Feature multiplicity similarity (MS), the Pfam clan similarity (CS), and the Feature positional similarity (PS). The score is calculated between Q and every protein in a pre-annotated search proteome resulting in a list where the proteins in the search proteome are ranked in decreasing order according to their FACT score. (D) From the score list any protein P can be extracted and its feature architectures similarity to Q can be visualized in the feature dotplot.

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