A. Summary of the biological results. The number of local co-evolving groups and the number of enriched co-evolving groups (in brackets) that were found in each of the biological datasets according to each of the co-evolution measures. B. A global view at the co-evolving functions (GO groups) in the yeast and the Eukaryote datasets, and the appearance time of each of the analyzed biological groups. C. An illustration of the break in co-evolution along the subtree of the Plantae.