The relationship between CMAD, MIDD and RMSD. A: relationship between the CMAD and the RMSD. Each dot represents a pair of the CMAD and the RMSD. The relationship was only showed when the CMAD< = 1.2Å, because the CMAD cutoff was set as 1.2Å. The green line represents the line of Y = X. B: relationship between the MIDD and the RMSD, The green line also represents the line of Y = X.