Figure 4
From: Forward-time simulation of realistic samples for genome-wide association studies
An initial population of 170 independent individuals of the JPT+CHB population of Phase 3 of the HapMap data set was expanded to large populations and subjected to slow (B, D, F) and rapid (C, E, G) selective sweeps at locus rs2173746. The trajectories of the frequencies of allele T at this marker in simulations after slow (B) and rapid (C) sweeps are plotted. The LD maps of 500 markers on chromosome 2 of the initial population (A), and 100 markers around locus rs2173746 of expanded populations after the slow (D) and rapid (E) sweeps are plotted. 1000 cases and 1000 controls were drawn from these expanded populations. The negative of the base 10 logarithm of p-values at 500 markers are plotted for slow (F) and rapid (G) sweeps.