Figure 2

Two examples of nucleosome epigenomic variation. A Top view of 4 SNP variants rs6055249, rs7508868, rs6140378, and rs2064267 (numbered 1-4 respectively) within a non-coding histone of chromosome 20:7602872-7603018. The histone position was obtained from [18], the SNPs were taken from a recent study examining variants associated with HDL cholesterol [19]. Such images may reveal structural relationships between non-coding region SNPs and histone phasing. B Side view of A. C A series of histone trimethylations within ENCODE region ENr111 on chromosome 13:29668500-29671000 [27]. The histone bp positions are from [18]. Each histone protein is shown as an approximate cylinder wedge: H2A (yellow), H2B (red), H3 (blue), H4 (green). The CA backbones of the H3 and H4 N-terminal tails are modeled using the crystal structure of the NCP (PDB 1A0I) [28]. The bright yellow spheres indicate H3K4me3 and H3K9me3, and the orange spheres are H3K27me3, H3K36me3 and H3K79me3.