Estimated g -functions, forward direction, ENCODE data. Plots of the g-functions modeling the effect of the occurrence of one TRE (column) on the occurrence of another TRE (row). The effects are estimated in the multivariate model adjusting for the histone modifications and allowing different baseline intensities for the ENCODE regions. A value less than one indicates that this inter-TRE distance tends not to occur while a value greater than one indicates an inter-TRE distance that is likely. Point-wise 95% confidence intervals for the functions are also shown.