Tests for local independence, ENCODE data. This figure shows results for the 64 parallel likelihood ratio tests for local independence between all pairs of the 8 TREs in the multivariate model adjusting for histone modifications and different baseline intensities. We show the results for the model estimated in the forward direction (squares, effect of TRE (column) on TRE (row)) as well as in the reverse direction (circles, effect of TRE (row) on TRE (column)). The size of the symbol for each test corresponds to the magnitude of the test statistic. Correcting for multiple testing using Holm's procedure the hypotheses of local independence that are rejected are shown in red while the hypotheses that are not rejected are shown in blue.