Comparative study of three commonly used continuous deterministic methods for modeling gene regulation networks

BMC Bioinformatics

Table 1 Method characteristics

Characteristic	ANN	SS	GRLOT
number of parameters	N * (N + 3)	N * (2 * N + 2)	N * (2 * N + 1)
limitation (saturation and sigmoidicity) of expression rates	yes	no	yes
Processing of multiple signals	additive, logical disjunction (OR)	multiplicative, logical conjunction (AND) corresponds well with collision theory	multiplicative, logical conjunction (AND) corresponds well with collision theory
regulation of degradation processes	no	yes	no
singularities	no	yes	no

Characteristics of the artificial neural network (ANN), the S-system (SS) and the General Rate Law Of Transcription (GRLOT) methods.

ISSN: 1471-2105