Figure 4

Phylogenetic profiles for each ensemble. Boxplots of the phylogenetic profile differences for edges across the assessed null model ensembles. The red line shows the average phylogenetic profile difference found for edges found in the LC graph. The observed phylogenetic difference found between PPIs in LC is significantly less than seen in the graphs sampled from each random null model, although the network shuffle graphs exhibit lower differences than the random graph ensemble graphs. The results are also shown for ensembles constrained using the GO and complex annotations.