Figure 5

Prediction of T cell epitopes using MHCI-peptide binding and cleavage models. A) ROC curves depicting the prediction of T cell epitopes restricted by A*0201 using MHCI-peptide binding prediction alone (black line) or in combination with cleavage predictions by the immunoproteasome (purple line), the proteasome (grey line) and both cleavage models together (blue line). B) AUC values obtained for the prediction of T cell epitopes restricted by 5 different HLA I molecules (A*0201, A*0301, A*2402, B*0702, B*2705) using MHCI-peptide binding predictions alone (black bars) and in combination with cleavage predictions by the immunoproteasome (purple bars), proteasome (grey bars) and both cleavage models together (blue bars). Significant increases (p < 0.05) in AUC values with regard to MHCI-peptide binding predictions alone (black bars) are indicated with the symbol "*". C) Reduction of false positives. The figure represents the decrease in percentage of false positives after introducing cleavage predictions by the immunoproteasome (purple bars), the proteasome (grey bars) and both together (blue bars). False positive reduction was computed over the entire ROC analysis.