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Table 4 Associations with gene mutations

From: An integrated analysis of molecular aberrations in NCI-60 cell lines

mutated gene

N 1

N 2

gene

logratio

pvalue

CDKN2A

78

70

*MDM2

3.156

1.790e-02

TP53

43

49

*FDXR

3.065

< 1.000e-04

PIK3CA

49

12

*HSPB8

3.000

1.770e-02

PTEN

25

20

*THBS2

2.901

6.140e-02

KRAS

13

13

*CDKN1A

2.350

1.400e-03

APC

14

8

*TNFRSF10B

2.348

3.700e-03

   

LTBR

2.296

< 1.000e-04

   

EGFL7

2.163

1.500e-03

   

*BAX

2.154

9.900e-03

   

TMEM5

2.008

1.400e-03

  1. Columns 1-3: number of gene expressions associated with each gene mutation in either direction. N1: # positively associated genes, N2: # negatively associated genes. Columns 4-6: top gene expressions negatively associated with TP53 mutation. Genes marked by asterisks are known TP53-regulated targets.
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BMC Bioinformatics

ISSN: 1471-2105

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