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Table 4 Associations with gene mutations

From: An integrated analysis of molecular aberrations in NCI-60 cell lines

mutated gene N 1 N 2 gene logratio pvalue
CDKN2A 78 70 *MDM2 3.156 1.790e-02
TP53 43 49 *FDXR 3.065 < 1.000e-04
PIK3CA 49 12 *HSPB8 3.000 1.770e-02
PTEN 25 20 *THBS2 2.901 6.140e-02
KRAS 13 13 *CDKN1A 2.350 1.400e-03
APC 14 8 *TNFRSF10B 2.348 3.700e-03
    LTBR 2.296 < 1.000e-04
    EGFL7 2.163 1.500e-03
    *BAX 2.154 9.900e-03
    TMEM5 2.008 1.400e-03
  1. Columns 1-3: number of gene expressions associated with each gene mutation in either direction. N1: # positively associated genes, N2: # negatively associated genes. Columns 4-6: top gene expressions negatively associated with TP53 mutation. Genes marked by asterisks are known TP53-regulated targets.