Table 5 Top tissue-specific patterns of gene expressions and the associated molecular aberrations. CNV: copy number variation, mut: mutation, meth: DNA methylation.
From: An integrated analysis of molecular aberrations in NCI-60 cell lines
tissues | # genes | aberrations | functions |
|---|---|---|---|
leukemia | 682 | seg 17, 11 CNV | nuclear transport, splicing, cell cycle, RNA synthesis, DNA replication |
melanoma | 465 | seg 9, 10 CNV, PAX3 meth. | glycogen metabolism, melanosome, transporter |
colon | 402 | seg 33 CNV, APC TP16 mut. | liver development, cell cycle |
CNS | 334 | seg 2, 49 CNV | - |
kidney | 251 | - | apoptosis, transport, ion binding, cell shape |
colon, leukemia | 198 | seg 11 and 33 CNV | DNA replication, translation |
breast | 147 | seg 16 CNV | endoplasmic reticulum |
ovarian | 106 | - | estrogen receptor |