Skip to main content
Figure 3 | BMC Bioinformatics

Figure 3

From: Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines

Figure 3

Drug-Reaction Network (DRN). DRN is generated by using the known interactions between approved drugs and their target reactions. Circles and triangles correspond to drugs and reactions, respectively. An edge between a drug node and a reaction node is placed if the drug targets at least one enzyme of the reaction. The area of the drug (reaction) node is proportional to the number of reactions (drugs) the drug (reaction) interacts with. Drug nodes are colored according to their Anatomical Therapeutic Chemical Classification, and reactions are colored according to their subsystems obtained from human metabolic network data.

Back to article page