Examination of the relationship between essential genes in PPI network and hub proteins in reverse nearest neighbor topology

Table 2 Comparison of "proportion of essential proteins identified" (recall) based on merged RNN cluster and that based on random selection of the same number of proteins in PPI network.

Organism	PPI network	*Recall*(merged RNN cluster)	*Recall*(random selection)	p-value
E Coli	DIP Core	0.89	0.09	0.0002
Yeast	DIP Core	0.73	0.19	0.0116
	Krogan	0.81	0.27	0.0183
	Gavin	0.85	0.40	0.0036
	Collins	0.79	0.31	0.0110
	HC	0.87	0.29	0.0014

Results were based on different PPI networks. p-value indicates the probability that the recall value is obtained based on random selection of proteins.

ISSN: 1471-2105