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Table 3 The effect of removal of RNN clusters on the change of topological properties of yeast HC PPI network.

From: Examination of the relationship between essential genes in PPI network and hub proteins in reverse nearest neighbor topology

Remove top % RNN clusters

0%

10%

20%

50%

100%

p-value

Average Degree per protein

6.18

5.61 (5.94)

4.94 (5.83)

4.15 (5.39)

3.55 (4.79)

0.021

Average Betweenness per protein

0.190

0.073 (0.210)

0.0069 (0.207)

0.063 (0.196)

0.057 (0.192)

0.002

Average Closeness per protein

0.103

0.084 (0.088)

0.080 (0.084)

0.065 (0.081)

0.059 (0.074)

0.023

  1. Values in brackets were based on random removal of the same number of proteins as in top % RNN clusters. p-values were associated with observing changes by random removal in PPI network.