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Table 4 The enrichment of essential proteins in merged RNN clusters for GO sub-networks in the yeast HC PPI network.

From: Examination of the relationship between essential genes in PPI network and hub proteins in reverse nearest neighbor topology

GO term

Name

Proportion of essential proteins in

  

GO sub-network

GO sub-network and merged RNN clusters

GO sub-network but not in merged RNN clusters

GO:0042254

ribosome biogenesis

0.69

0.85

0.63

GO:0016070

RNA metabolic process

0.48

0.66

0.41

GO:0006997

nucleus organization

0.47

0.60

0.44

GO:0007059

chromosome segregation

0.47

0.50

0.46

GO:0070271

protein complex biogenesis

0.44

0.67

0.39

GO:0007049

cell cycle

0.36

0.48

0.34

GO:0044257

cellular protein catabolic process

0.36

0.81

0.21

GO:0006350

transcription

0.35

0.50

0.30

GO:0006259

DNA metabolic process

0.33

0.44

0.30

GO:0006457

protein folding

0.33

0.13

0.36

GO:0051276

chromosome organization

0.30

0.37

0.28

GO:0006810

transport

0.29

0.52

0.26

GO:0016192

vesicle-mediated transport

0.27

0.55

0.22

GO:0006412

translation

0.25

0.47

0.21

GO:0016044

membrane organization

0.24

0.46

0.21

GO:0006464

protein modification process

0.20

0.38

0.16

GO:0006950

response to stress

0.20

0.39

0.16

GO:0000746

conjugation

0.19

0.20

0.18

GO:0007126

meiosis

0.17

0.35

0.14

GO:0044262

cellular carbohydrate metabolic process

0.17

0.57

0.14

GO:0007165

signal transduction

0.15

0.30

0.13

GO:0019725

cellular homeostasis

0.08

0.08

0.08

GO:0042221

response to chemical stimulus

0.07

0.17

0.06

  1. Each of the GO sub-networks contains at least one merged RNN cluster; the proportion of essential proteins in "proteins in GO sub-network", "proteins in GO sub-network and also in merged RNN clusters", and "proteins in GO sub-network but not in merged RNN clusters".