Skip to main content
Figure 5 | BMC Bioinformatics

Figure 5

From: Proteome scanning to predict PDZ domain interactions using support vector machines

Figure 5

Comparison of proteome scanning performances for SVM and published predictors. A comparison of predictor performance evaluated using F1 measures and FPRs for 13 human (blue), 6 worm (green) and 7 fly (black) PDZ domains. Three different predictors were compared: MDSM, additive model and a PWM predictor. PDZBase interactions were used to validate human predictions. Protein microarray interactions from Chen et al. were used to validate fly and worm predictions. The median is denoted by the red circle. No FPRs were calculated for human predictions since there are no negative human validation interaction data. MDSM and the additive model were trained in their original publications using mouse protein microarray data only. The PWM predictor was trained using the same mouse and human data as the SVM.

Back to article page