Figure 1
From: Trimming of mammalian transcriptional networks using network component analysis
A schematic overview of the method. The TFA perturbations are estimated in an iterative fashion that trims unimportant edges from the regulatory (connectivity) network. If the data set is not NCA-compliant, additional data are generated in silico before estimating the TFA perturbations. Then, the significance of the TFA perturbations is assessed using the z-test and null distributions created by random sampling of expression data across the whole genome.