Figure 4
From: Quadratic variance models for adaptively preprocessing SELDI-TOF mass spectrometry data
Trade off between sensitivity and false discovery rate for LibSELDI and MassSpecWavelet. Average loess-smoothed operating characteristics show the trade-offs between sensitivity (TPR) and false discovery rate (FDR) for HYBRID1 and HYBRID2. The mean loess-smoothed curve is indicated by the solid line, while the upper and lower dashed lines indicate the 75% and 25% quartile curves. The FDR axis is shown in log-scale to emphasize lower FDR values. LibSELDI demonstrates superior sensitivity compared to MassSpecWavelet on both datasets for FDR values less than about 25%. MassSpecWavelet has the advantage for FDR values greater than 25%.