Figure 6

Illustration of large-scale cluster structures in the gene-disease-protein complex network. The large-scale decomposition of the gene-disease-protein complex network is illustrated as described in Figure 2b. The hierarchical clustering of the nodes' degrees of membership of the (a) complex, (c) gene and the (d) disease partition show that the majority of elements was assigned to single clusters. However, a considerable amount of cluster overlaps exists, e.g. for the disease clusters 3 and 4. The backbones for gene-complex (b) and for gene-disease (e) are sparsely connected, but show that locally overlapping clusters tend to interconnect with the same clusters of the other partition; e.g. disease cluster 3 and 4 are both connected to gene cluster 9 with large weights.