Figure 8

The small-scale clustering in the neighborhood of MECP2. We draw the results - the backbone network and the nodes' degrees of membership to clusters, thresholded by μ > 0.2 - of the small-scale clustering in the neighborhood of MECP2 using the fuzzy (a) and the hard clustering (b). Nodes are colored according to their disorder class annotations. Blue edges indicate backbone interconnectivity, grey edges cluster assignment. Edge thickness indicates the degree of membership. MECP2 is connected to three gene clusters mainly covering neurological (red) and psychiatric (purple) genes. The seven interconnected disease clusters also represent mainly psychiatric and neurological disorders. Also unclassified disorders are present such as e.g. Alcohol dependence (white), which is classified as a mental and behavioral disorder. In a broader sense, however, it can be considered as psychiatric disorder. Applying the hard clustering (b), MECP2 is assigned to gene cluster 209 which is connected to two disease clusters only. Although all associated disorders are identified correctly, in contrast to the fuzzy clustering no further information can be obtained from the decomposition.