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Table 4 Performance of the prediction of NMA-derived B-factors (BNMA) from PSSM, the observed and predicted values and their combination of the equilibrium structural features (ESFs).

From: Integrated prediction of one-dimensional structural features and their relationships with conformational flexibility in helical membrane proteins

Input features

Prediction performance (Correlation with BNMA)

Prediction performance (Correlation with randomized BNMA)

P-value

PSSM (9 residue window) and amino acid composition

0.21

-0.02

1.3e-7

ESFs (Observed)

0.52

0.00

< 2.2e-16

ESFs (Predicted)

0.23

-0.01

4.1e-10

ESFs (Predicted + Observed)

0.46

-0.01

< 2.2e-16

  1. Performance on randomized BNMA is shown for reference and a p-value is calculated using Welsh's t-test on the two sets of protein-wise performance scores (correlation coefficients). The predicted ESFs alone can predict BNMA with reasonable performance.
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BMC Bioinformatics

ISSN: 1471-2105

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