Detailed overview of HOPE's components. HOPE's input consists of the sequence and the mutation. The sequence is used for a BLAST search against the databases. Using the accession code (and PDB-file if available) HOPE can collect information from a series of information sources: WHAT IF calculations on the PDB-file or homology model built by YASARA, annotations in the Uniprot database, HSSP conservation scores and sequence-based predictions by DAS-servers. The information is combined in a decision scheme and a report is generated. This report is illustrated with pictures and animations and difficult keywords are linked to our own online dictionary.