LabelHash results for ES motif based on [PDB:2MNR]. Dark gray denotes matches to structures in the ESdb as defined by Meng et al.  while light gray denotes matches to structures in the nrPDB95. The dashed line in each plot corresponds to the p-value threshold at α = 0.01. (a) The clear separation of the distributions of ESdb and nrPDB95 matches identified using minimum side-chain RMSD illustrates the high-specificity of the 2MNR-based motif. (b) Examining the distributions of matches based upon C
RMSD demonstrates the inseparability of ESdb matches from the majority of nrPDB95 structures if minimum C
RMSD is used alone for match selection.