Figure 4
From: Epigenetic domains found in mouse embryonic stem cells via a hidden Markov model
Average within-domain variance of a modification versus a random distribution. Two-state model (K = 2) results (and corresponding permutation test p-values) are shown in red, three-state in blue (K = 3), random distribution shown in black. For four of the modifications, the HMM domains have a significantly lower average variance (H3K4me2, H3K4me3 & H3K27me3: p-values < 0.001), suggesting that the HMM has produced coherent domain bounds.