F-score curves for S. cerevisiae PPI dataset. F1 score (harmonic mean of precision and recall) evaluations of semantic similarity measures at different cutoffs based on the S. cerevisiae PPI dataset derived from DIP are shown. The evaluation was performed using cellular component, biological process, and molecular function ontologies of GO. Maximum (MAX) approach for combining multiple annotations was used on a dataset with only manual annotations (no electronic annotations (IEA-)). F1 score reaches its best value at 1 and worst at 0. TCSS does better than Resnik for semantic similarity cutoff scores in all three ontologies.