Figure 6

Results for PARP2 gene (data from GSE9372). According to Kwan et al. [21], this gene shows AS related to a particular SNP in probeset 3527423 and it has a new variant with its second exon shortened. The content of each panel is explained in figure 4. (b) Residuals of the RMA normalization model. For some exons there are residuals much larger than for others, as at the end of the second exon where the probeset 3527423 is located. (g) There is a splicing event at the end of the second exon which correspond to probeset 3527423 in transcript variant 2. Transcript variant 1 matches Ensembl annotated transcript. (h) Estimated concentration of each variant with three replicates per transcript. These concentrations match RT-PCR results perfectly.