Figure 5

Manhattan plots of the results of a single-marker (left) and V-Bay GWA analysis (right) of the gene expression product HLA-DRB1 for individuals in HapMap. Each dot reflects the -log₁₀ p-value resulting from the single-marker analysis (left) and the -log10 p-vbay output of V-Bay (right), where non-significant associations are represented as blue dots (alternating shades are used to distinguish chromosomes). The markers above the red line for the single-marker analysis are significant when using a Bonferroni correction. The marker in red for the V-Bay analysis (in the black line) is significant at an equivalently conservative false positive control. Note that the lasso was also able to identify this association. We did not incorporate the SNPs on the X and Y chromosomes in our analyses.