Skip to main content

Table 2 Comparison of V-Bay and single-marker GWA analysis of simulated data for 1 million markers.

From: A variational Bayes algorithm for fast and accurate multiple locus genome-wide association analysis

sample

loci

(min/max)a

V-Bay min

single-marker min

200

4

0.24 (0.0032/0.75)

0.83

0.026

98.9

0.55

0.16

87.4

200

32

0.028 (6.7e-5/0.28)

0.053

0.033

26.9

0.072

0.050

35.3

1000

4

0.23 (0.0050/0.65)

1.00

0.0050

100

0.78

0.045

98.7

1000

32

0.028 (8.3e-5/0.30)

0.61

0.0037

95.6

0.32

0.0099

78.2

  1. Phenotypes were simulated with a fixed total heritability of 0.9. The false positive rate was controlled to be < 10-7 for both the V-Bay analysis and the single-marker analysis. (: average true positive rate)
  2. aAverage, maximum, and minimum individual heritabilities of the individual loci.
  3. bThe smallest individual heritability identified among the true positives.
  4. cThe average total heritability accounted for by the true positives identified.