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Figure 3 | BMC Bioinformatics

Figure 3

From: Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation

Figure 3

Illustration of GraDe. For the bifan motif in a we take 6 genes (dots) from the simulated time-courses in b (for parameters see Additional file 1) and apply GraDe: c shows the eigenvalues of the decomposition in GraDe. In d we plot the time-courses of the extracted sources s1 ... s6, hence the curves are the columns of the mixing matrix. From c we see that only the first three sources are relevant, which are visualized as heat-map e. For our second example f we assume to know expressions in different conditions as shown in g. The factorization by GraDe is visualized in sub figures h to j.

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