Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation

BMC Bioinformatics

Table 1 Main biological processes in response to IL-6

Source	Mode	Biological process
1	positive	(external) stimulus, inflammatory response
	negative	(fructose) metabolic process
2	positive	early cell cycle and division
	negative	metabolic process, apoptosis
3	positive	late cell cycle and division
	negative	-
4	positive	translation, coagulation
	negative	(protein) metabolic process

Summary of the main biological processes in hepatocytes regulated as response to IL-6. Mode indicates genes with significant positive (≥2) or negative (≤-2) contribution to the source. The main biological processes found for the corresponding group of genes are given in the last column.

ISSN: 1471-2105