Performance of RNA secondary structure prediction by maximizing the pseudo-expected MCC with the stochastic sampling (Method M1). Performance of RNA secondary structure prediction by "X-Max-pMCC (N)" means the estimator of Eq. (23) with model X and number of samples N with respect to MCC. In the figure, we have also plotted the SEN-PPV curves of the γ-centroid estimator  with the CONTRAfold model ("CONTRAfold-gCentroid"; the black line) and with the McCaskill model ("McCaskill-gCentroid"; the gray line). The points and curve in gray and those in black indicate the McCaskill  and CONTRAfold  models, respectively. See Additional file 1, Figure S3 in the supplementary paper for the results of F-score.