Performance of RNA secondary structure prediction with the γ-centroid estimator and the pseudo-expected MCC/F-score (Method M2). Performance of RNA secondary structure prediction with the γ-centroid estimator and the pseudo-expected MCC (F-score) (the estimator Eq. (24) with MCC (F-score); Method M2); "X-gCentroid-pMCC" ("X-gCentroid-pF") where X is the McCaskill or CONTRAfold model. The curves (X-gCentroid) indicate the performance of the γ-centroid estimator  with the McCaskill model and the CONTRAfold model. For comparison, we have also plotted the performance of RNAfold , Sfold  and Simfold  (red points). See Additional file 1, Figure S4 for performances of MEA estimators used in Do et al. .