Figure 2From: A novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting relative thermostability of protein mutantsAmino acid substitutions between mesophilic and hyperthermophilic proteins. The top number in each cell is the observed substitution instances and the bottom one (in italics) is the ratio of the number of the substitution cases to the opposite substitution. Significant biased substitutions (p-value < 10-10, two-sided Fisher's exact test) are highlighted in bold. Red cells are significant HP favored substitutions while blues are MP favored.Back to article page