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Figure 1 | BMC Bioinformatics

Figure 1

From: MLPAinter for MLPA interpretation: an integrated approach for the analysis, visualisation and data management of Multiplex Ligation-dependent Probe Amplification

Figure 1

MLPAinter for MLPA interpretation. Panel A: Heat map of an authorised series of samples after normalisation. The probes are sorted by the name of the gene. The gain and loss columns show the total number of probes with gain or loss. Q1-3 show the different quality scores calculated from the DNA dependent probes (marked 101-104) and the ligation dependent probe (105) and as explained in the text. Dark grey cells: calibration probes, the id has a suffix 'c'. Light grey cells: reference probes, the id has a suffix 'r'. Yellow cells: probes with loss of one allele (< 0.8). Blue cells: probes with gain of one allele (>1.25). Panel B: Sample plot of an individual sample after normalisation. The quality indices for each replicate are shown. Replicates are visualised in different colours. Probes are sorted by the gene name combined with the chromosomal position. The standard scale can be adjusted in case of samples with amplified probes (see panel C).

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