Flowchart of GENS. Starting from desired population characteristics, GENS assigns to each individual the genotypes of genetic factors and the exposure levels of environmental factors. Beside, the module KAPS uses population characteristics to compute coefficients of the Multi-Logistic Model. Thus, on the basis of individual characteristics and Multi-Logistic Model, the individual disease risk is computed. The last step is the assignment of disease status to individuals (affected/not affected) according to their disease risks.