Table 2 Parameters required by GENS. Description of parameters required by GENS in order to produce a simulated case-control sample. These parameters are translated into coefficients for the Multi-Logistic Model by the Knowledge-Aided Parametrization System.
From: A novel approach to simulate gene-environment interactions in complex diseases
Parameter | Description |
|---|---|
N | Number of individuals |
G | Number of genetic factors |
E | Number of environmental factors |
PG( | Frequency of genotype i a of genetic factor ga(a = 1, ..., G) |
PE( | Exposure probabilities, where b = 1, ..., E and j b is an index which runs over the possible discretized values of the variable b |
m | Overall disease frequency in the population |
TypeOfGxe | Type of GxE: Genetic (GM), Environmental (EM), Gene Environment interaction (GEM, Additive (AM) |
RR 31 | Relative risk of high-risk homozygote |
W | Model of inheritance: recessive (W = 0), dominant (W = 1), co-dominant (0 <W < 1) |
β | Odds ratio of the disease risk of an individual exposed to x j with respect to one exposed to x j + 1 |
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