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Table 2 Reactions involved in the MEP pathway (in order of occurrence)

From: Simulation of a Petri net-based Model of the Terpenoid Biosynthesis Pathway

Ordera Reaction Enzyme Main productb
A G3P + pyruvate → DXP + CO2 DXP synthase (EC 2.2.1.7) DXP
B DXP + NADPH + H+ → MEP + NADP+ deoxyxylulose phosphate reductoisomerase (DXR; EC1.1.1.267) MEP
C MEP + CTP → CPP-ME + diphosphate MEP cytidyltransferase (EC 2.7.7.60) CPP-ME
D CPP-ME + ATP → pCPP-ME + ADP CPP-ME kinase (EC 2.7.1.1480) pCPP-ME
E pCPP-ME → CMP + MEcycPP MEcycPP synthase (EC4.6.1.12) MEcycPP
F MEcycPP + protein diol → HMBPP + H2O + protein disulfide HMBPP synthase (EC 1.17.4.3) HMBPP
G HMBPP + NADPH + 2H+ → IPP + DMAPP + H2O + NADP+ HMBPP reductase (EC 1.17.1.2) IPP dan DMAPP
H IPP + DMAPP → GPP GPP synthase (EC 2.5.1.10 atau EC 2.5.1.1) GPP
I GPP → monoterpenoid monoterpene synthase monoterpenes
  1. a Order of occurrence in the MEP pathway
  2. b Main product that serves as the substrate for the next reaction in the MEP pathway