Evolutionary histories that explain why for a query protein in human, we find both a close and a distant homolog in yeast. Some proteins for which we recover a distant homolog in yeast with our method, in fact have a better hit (a closer homolog) in yeast. The three scenario's depicted here could have this effect. We test which scenario occurs more often by looking whether the distant homolog in yeast (Yeast2 in this Figure) have a closer homolog in human than Human1. Red square: gene duplication event, green circle: speciation event.