PostMod: sequence based prediction of kinase-specific phosphorylation sites with indirect relationship

BMC Bioinformatics

Table 4 Average performance of 10-fold cross validation.

Kinase	New method			Kinase	New method			Kinase	New method
	ACC	P	R		ACC	P	R		ACC	P	R
CDK_group	0.92	0.60	0.88	MAPK3	0.93	0.61	0.73	CDK1	0.94	0.63	0.90
GSK-3_group	0.88	0.32	0.17	MAPK1	0.94	0.66	0.80	CDK2	0.94	0.65	0.87
PLK1	0.90	0.00	0.00	MAPK8	0.91	0.53	0.83	CK2 alpha	0.95	0.76	0.66
GRK_group	0.91	0.15	0.07	Lck	0.92	0.75	0.20	Lyn	0.92	0.67	0.23
EGFR	0.92	0.69	0.42	PKC_group	0.92	0.76	0.30	RSK_group	0.96	0.80	0.85
MAPK14	0.93	0.67	0.60	Src	0.92	0.69	0.27	DNA-PK	0.88	0.40	0.35
InsR	0.93	0.62	0.45	IGF1R	0.95	0.76	0.70	Aurora	0.92	0.58	0.26
CK2_group	0.94	0.71	0.58	ATM	0.96	0.87	0.70	Met	0.96	0.80	0.85
AMPK_group	0.94	0.60	0.27	Abl	0.93	0.77	0.30	PHK_group	0.90	0.10	0.05
MAPKAPK2	0.92	0.63	0.33	PDK-1	0.96	0.86	0.67	GRK-2	0.94	0.30	0.15
CK1_group	0.90	0.20	0.10	PKA alpha	0.95	0.78	0.57	ROCK_group	0.94	0.70	0.35
PKA_group	0.95	0.81	0.59	IKK_group	0.91	0.43	0.20	FGFR1	0.89	0.10	0.05
PKC alpha	0.92	0.69	0.28	CaM-KIIalpha	0.94	0.65	0.37	PDGFR	0.94	0.70	0.45
Syk	0.94	0.86	0.54	GSK-3beta	0.90	0.32	0.12	CK1	0.93	0.55	0.23
Fyn	0.90	0.25	0.13	CaM-KII_group	0.92	0.62	0.20	CDK5	0.97	0.87	0.75
MAPK_group	0.92	0.64	0.54	PKB_group	0.94	0.93	0.41	PAK1	0.94	0.50	0.25

The mean accuracy, precision, and recall of the new method for 48 kinases are 0.93, 0.59, and 0.43, respectively.

ISSN: 1471-2105