Integration of multiple data sources to prioritize candidate genes using discounted rating system

BMC Bioinformatics

Table 2 The performance of three combination algorithms on each disease family, measured by AUC values (%).

SN	Disease Family	No. of Disease Genes	AUC Value(%)
			DRS	WDRS	NDOS
1	Amyotrophic lateral sclerosis	8	87.5	87.3	90.0
2	Age-Related Macular Degeneration	12	79.7	80.2	79.8
3	Bardet-Biedly Syndrome	13	86.5	87.2	84.5
4	Breast Cancer	15	89.0	89.9	91.5
5	Chondrodysplasia punctata	14	98.6	99.1	98.6
6	Noonan Syndrome, Costello syndrome, Cardiofaciocutaneous Syndrome	9	97.6	97.9	99.0
7	Hypertrophic cardiomyopathy	15	84.1	84.0	84.0
8	Congenital myasthenic syndromes	10	99.9	99.9	99.8
9	Charcot Marie Tooth Disease	24	85.2	86.1	85.8
10	Cataract	11	83.8	84.0	83.0
11	Dilated cardiomyopathy	20	93.3	93.9	93.1
12	Epidermolysis bullosa	16	99.5	99.6	99.4
13	Ehlers Danlos syndrome	8	97.3	97.4	97.6
14	Esophageal carcinoma	10	90.4	91.5	87.4
15	Essential hypertension	12	87.2	89.3	85.0
16	Fanconi anemia	12	99.5	99.6	98.8
17	Glioma of brain	21	86.6	86.5	87.1
18	Hereditary nonpolyposis colorectal cancer	7	96.7	96.9	96.1
19	Hermansky-Pudlak syndrome	8	99.5	99.6	99.1
20	Inflammatory Bowel Disease	8	85.4	87.9	87.6
21	Leber congenital amaurosis	9	88.0	96.9	86.1
22	Limb-Girdle Muscle Dystrophy	14	96.1	96.8	94.9
23	Long QT Syndrome	9	95.9	96.3	95.7
24	Leigh Syndrome	24	72.8	73.4	73.2
25	Microphthalmia	9	83.4	85.1	87.3
26	Mitochondrial complex I deficiency disorders	16	84.1	84.0	84.1
27	Maturity-Onset Diabetes of the Young	19	82.7	85.6	82.6
28	Nonsyndromic hearing loss	47	95.8	96.5	94.7
29	Obesity	13	96.9	97.2	98.3
30	Parkinson	8	94.4	95.0	97.6
31	Pheochromocytoma	10	78.3	80.7	82.2
32	Retinitis Pigmentosa	23	96.4	98.7	95.1
33	Spinocerebellar Ataxia	13	73.2	75.6	73.7
34	Thyroid carcinoma	8	75.5	80.4	78.8
35	Xeroderma Pigmentosum	8	99.8	99.8	99.9
36	Prostate Cancer	14	80.8	84.7	81.9

ISSN: 1471-2105