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Table 2 The performance of three combination algorithms on each disease family, measured by AUC values (%).

From: Integration of multiple data sources to prioritize candidate genes using discounted rating system

SN Disease Family No. of Disease Genes AUC Value(%)
    DRS WDRS NDOS
1 Amyotrophic lateral sclerosis 8 87.5 87.3 90.0
2 Age-Related Macular Degeneration 12 79.7 80.2 79.8
3 Bardet-Biedly Syndrome 13 86.5 87.2 84.5
4 Breast Cancer 15 89.0 89.9 91.5
5 Chondrodysplasia punctata 14 98.6 99.1 98.6
6 Noonan Syndrome, Costello syndrome, Cardiofaciocutaneous Syndrome 9 97.6 97.9 99.0
7 Hypertrophic cardiomyopathy 15 84.1 84.0 84.0
8 Congenital myasthenic syndromes 10 99.9 99.9 99.8
9 Charcot Marie Tooth Disease 24 85.2 86.1 85.8
10 Cataract 11 83.8 84.0 83.0
11 Dilated cardiomyopathy 20 93.3 93.9 93.1
12 Epidermolysis bullosa 16 99.5 99.6 99.4
13 Ehlers Danlos syndrome 8 97.3 97.4 97.6
14 Esophageal carcinoma 10 90.4 91.5 87.4
15 Essential hypertension 12 87.2 89.3 85.0
16 Fanconi anemia 12 99.5 99.6 98.8
17 Glioma of brain 21 86.6 86.5 87.1
18 Hereditary nonpolyposis colorectal cancer 7 96.7 96.9 96.1
19 Hermansky-Pudlak syndrome 8 99.5 99.6 99.1
20 Inflammatory Bowel Disease 8 85.4 87.9 87.6
21 Leber congenital amaurosis 9 88.0 96.9 86.1
22 Limb-Girdle Muscle Dystrophy 14 96.1 96.8 94.9
23 Long QT Syndrome 9 95.9 96.3 95.7
24 Leigh Syndrome 24 72.8 73.4 73.2
25 Microphthalmia 9 83.4 85.1 87.3
26 Mitochondrial complex I deficiency disorders 16 84.1 84.0 84.1
27 Maturity-Onset Diabetes of the Young 19 82.7 85.6 82.6
28 Nonsyndromic hearing loss 47 95.8 96.5 94.7
29 Obesity 13 96.9 97.2 98.3
30 Parkinson 8 94.4 95.0 97.6
31 Pheochromocytoma 10 78.3 80.7 82.2
32 Retinitis Pigmentosa 23 96.4 98.7 95.1
33 Spinocerebellar Ataxia 13 73.2 75.6 73.7
34 Thyroid carcinoma 8 75.5 80.4 78.8
35 Xeroderma Pigmentosum 8 99.8 99.8 99.9
36 Prostate Cancer 14 80.8 84.7 81.9