Figure 3

Interaction map of all protein interfaces with tetraloops (a) atom distribution; the color scale goes from blue to red following the increasing atom density (number of atoms within a cell). The polygons with black perimeters mark the regions corresponding to the backbone of the tetraloops, labeled 1 to 4 specifying the position of the nucleotides (b) The interaction map is colored according to the amino acid physico-chemical properties: yellow is hydrophobic, pink aromatic, cyan polar, blue positive, red negative, green proline. Gray is used for gap cells. Colors are more intense where the density is higher.