Table 1 Details of the common pattern calculated between the four PGH2 binding sites using MultiBind. PII (aromatic) interactions, hydrogen bond acceptor (ACC), or mixed donor-acceptor (DON, DAC) and Aliphatic interactions(ALI).
From: Comparison of PGH2 binding site in prostaglandin synthases
Site 1: PGES/1z9hB | Site 2: PGDS/2cvdD | Site 3:PGFS/2f38A | Site 4: PGIS/3b6hA | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Chain.ID | A. A. | Type | C hain.ID | A. A. | Type | Chain.ID | A. A. | Type | Chain.ID | A. A. | Type |
B.107 | Tyr | PII | D.9 | Phe | PII | A.24 | Tyr | PII | A.99 | Tyr | PII |
B.109 | Thr | PII | D.13 | Gly | PII | A.117 | His | PII | A.283 | Ala | PII |
B.109 | Thr | ACC | D.13 | Gly | ACC | A.117 | His | DAC | A.283 | Ala | ACC |
B.110 | Cys | ALI | D.14 | Arg | ALI | A.54 | Leu | ALI | A.283 | Ala | ALI |
B.246 | Ile | ALI | D.99 | Met | ALI | A.120 | Met | ALI | A.128 | Leu | ALI |
B.250 | Val | ALI | D.160 | Leu | ALI | A.318 | Pro | ALI | A.447 | Ala | ALI |
B.251 | Tyr | PII | D.163 | Phe | PII | A.319 | Tyr | PII | A.434 | Trp | PII |