Figure 3

An example of modular pleiotropy with a pleiotropic component related to the extracellular matrix. The modules shown are specific to microarray datasets that study "nervous system disorders," and "Neoplasms, Glandular and Epithelial." The shaded elliptical nodes represent genes associated with the module phenotype (via GeneRIF text mining), whereas the shaded diamond nodes represent predictions made by our random forest classifier. The edge opacity indicates how often a pair of genes was coexpressed in the microarray datasets for which the module was coexpressed.