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Figure 5 | BMC Bioinformatics

Figure 5

From: An integrative modular approach to systematically predict gene-phenotype associations

Figure 5

An example of modular pleiotropy with phenotype-specific regulatory data. The genes in the module on the left are specifically coexpressed in "Squamous Cell Neoplasms" microarray datasets, while those on the right are specifically coexpressed in "Immunoproliferative Disorders" microarray datasets. Two phenotype-specific modules containing genes with GeneRIF entries for the same phenotype (shaded). The edge opacity indicates how often a pair of genes was coexpressed in the microarray datasets for which the module was coexpressed. The opacity the edges indicates the degree of coexpression. The transcription factor binding, derived from ChIP-chip datasets that studied phenotypes related to the microarray datasets, is shown with dotted arrows.

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