Table 2 Overrepresented GO terms in predicted genes Seven of the UMLS phenotypes are highlighted, along with the number of phenotype-specific coexpression modules and number of novel predicted associated genes. The final column contains a subset of the overrepresented GO biological processes in the predicted genes that are consistent with the phenotype. The full table is available on our supplementary website.
From: An integrative modular approach to systematically predict gene-phenotype associations
Phenotype | Modules | Predictions | Over-represented GO annotations |
|---|---|---|---|
Adenocarcinoma | 2367 | 69 | cell cycle process (3.5e-06) DNA replication (4.1e-06) cell cycle phase (8.5e-06) |
Bone Marrow Cells | 5390 | 421 | immune response (3.8e-06) immune system process (7.2e-06) response to virus (2.0e-05) |
Brain | 8373 | 329 | synaptic transmission (3.8e-06) monovalent inorganic cation transport (1.7e-05) |
Connective and Soft Tissue Neoplasm | 1463 | 22 | cell cycle process (4.3e-14) cytoskeleton-dependent intracellular transport (8.6e-07) |
Musculoskeletal Diseases | 5421 | 324 | actin filament-based process (8.2e-06) |
Squamous cell carcinoma | 1268 | 54 | DNA replication (2.5e-08) keratinization (8.1e-05) epidermis development (1.0e-04) |
nervous system disorder | 8235 | 628 | respiratory electron transport chain (5.1e-07) acetyl-CoA catabolic process (3.2e-05) |