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Table 4 Enriched pathways of Liu-wei-di-huang genes and Liu-wei-di-huang-treated disease genes identified by DAVID

From: Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae

Category

Enriched KEGG pathway

False discovery rate

Liu-wei-di-huang genes

hsa05200:Pathways in cancer

1.82E-06

 

hsa05014:Amyotrophic lateral sclerosis

3.82E-06

 

hsa04620:Toll-like receptor signaling pathway

6.42E-06

 

hsa04660:T cell receptor signaling pathway

1.56E-05

 

hsa04210:Apoptosis

8.13E-04

 

hsa04621:NOD-like receptor signaling pathway

0.002737

 

hsa05222:Small cell lung cancer

0.00471

 

hsa04080:Neuroactive ligand-receptor interaction

0.007635

 

hsa05210:Colorectal cancer

0.03486

Liu-wei-di-huang-treated

hsa05200:Pathways in cancer

2.35E-12

disease genes

hsa05210:Colorectal cancer

1.11E-07

 

hsa05221:Acute myeloid leukemia

2.58E-07

 

hsa05213:Endometrial cancer

5.92E-07

 

hsa05220:Chronic myeloid leukemia

9.79E-05

 

hsa05215:Prostate cancer

1.38E-04

 

hsa04930:Type II diabetes mellitus

2.25E-04

 

hsa05218:Melanoma

3.68E-04

 

hsa05216:Thyroid cancer

0.002937

 

hsa05214:Glioma

0.005064

 

hsa05223:Non-small cell lung cancer

0.008102

 

hsa04950:Maturity onset diabetes of the young

0.01155

 

hsa05212:Pancreatic cancer

0.019292